Brown RG, Marchesi JR, Lee YS, Smith A, Lehne B, Kindinger LM, Terzidou V, Holmes E, Nicholson JK, Bennett PR, MacIntyre DA. Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin. BMC Med. 2018 Jan 24;16(1):9. doi: 10.1186/s12916-017-0999-x. MacIntyre DA, Chandiramani M, Lee YS, Kindinger L, Smith A, Angelopoulos N, Lehne B, Arulkumaran S, Brown R, Teoh TG, Holmes E, Nicoholson JK, Marchesi JR, Bennett PR. The vaginal microbiome during pregnancy and the postpartum period in a European population. Sci Rep. 2015 Mar 11;5:8988. doi: 10.1038/srep08988. Antiseptic treatment aimed at reducing potential bacterial overgrowth consisted of 10 days (1 box) of vaginal ovules of CLX (CumLaude CLX ® , CLX digluconate 0.2%) always starting between 10+0 and 16+0 weeks. All patients underwent an initial ultrasound examination between 6+0 and 15+6 weeks gestation, including assessment of embryo/fetus vitality. Aveti nevoie in primul rand de un tratament care sa restabileasca echilibrul florei vaginale, de exemplu Zenella med, care contine inulina, benefica bacteriilor sanatoase din flora vaginala.

Full Title of Study: “Evaluation of the Efficacy of Chlorhexidine Use During the First Trimester as a Regulator of Vaginal Microbiota in Reducing Preterm Birth” Study Type Statistical analysis and graphs were done using Graph Pad Prism®, Mac version 9.0.1, and Stat Plus® Mac Pro version 8.0.1.s. Efectul tonic si revigorant al extractului de Hamamelis il recomanda pentru utilizarea in zonele sensibile si delicate.

In cazul dumneavoastra, daca nu mai aveti mancarimi si secretii colorate (alb branzos, galben sau gri),urmati un tratament de 7 zile cu Zenella (1 comprimat dimineata, unul seara), apoi asteptati cateva zile si refaceti analizele de secretie vaginala. Este posibil sa va fi vindecat, dar secretia vaginala sa nu fie inca de consistenta si aspect normale din cauza afectiunilor prelungite. Leitich H, Kiss H. Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):375-90. doi: 10.1016/j.bpobgyn.2006.12.005. Epub 2007 Jan 22.

online παραγγελία. Ο χρόνος διεκπεραίωσης της παραγγελίας είναι 1 έως 3 εργάσιμες ημέρες, ενώ σε περιόδους μεγάλων προσφορών και αυξημένου όγκου παραγγελιών είναι 3 έως 5 ημέρες. Η παραγγελία σας θα κρατηθεί στο φαρμακείο μας μέχρι 5 ημερολογιακές ημέρες. Όταν εκπνεύσει το χρονικό περιθώριο ακυρώνεται αυτόματα από το σύστημά μας. Partenerul dumneavoastra a facut candidoza ca urmare a tratamentului cu Ciprofloxacina, poate lua fluconazol 150 mg, doza unica, cu repetare peste 7 zile. Poate aplica si crema pe baza de clotrimazol. In perioada tratamentului va trebui sa va protejati cu prezervativ. Antiseptic treatment aimed at reducing possible bacterial overgrowth consisted of 10 days (1 box) of CLX vaginal ovules (CLX digluconate 0.2%) always starting between 9+0 and 16+0 weeks.Box Now κοστίζει 2,30€ για παραγγελίες με μέγιστο βάρος 20 κιλά και διαστάσεις έως 62 x 45 x 36 cm. Participants were recruited at the routine first trimester consultation. All patients underwent an initial ultrasound examination between 6+0 and 15+6 weeks gestation, including assessment of embryo/fetus vitality. Brown RG, Marchesi JR, Lee YS, Smith A, Lehne B, Kindinger LM, Terzidou V, Holmes E, Nicholson JK, Bennett PR, MacIntyre DA. Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin. BMC Med. 2018 Jan 24;16(1):9. doi: 10.1186/s12916-017-0999-x. Citations Reporting on Results Finally, preterm birth incidence was calculated for specific groups selected according to the multivariable analysis result. Registra una identificación única que se utiliza para generar datos estadísticos acerca de cómo utiliza el visitante el sitio web.

The aim of this prospective observational study was to evaluate the efficacy of a universal strategy of primary prevention of preterm birth using intravaginal chlorhexidine (CLX) applied before 16 weeks. Clinical implications of the study: The clinical implications of our project would be to counteract the effect of pathogenic bacteria from the beginning of pregnancy (outside the teratogenic period) with the administration of the CLX ovules and thus enhance the action of the normal vaginal microbiota in the pregnant patient, since the glycogen available due to hormonal action favours the growth and development of lactobacillus, responsible for its protective activity against pathogens during pregnancy. Sample size: The approximate number of births per year in Spain is 370,000. The minimum number of patients to be recruited would be 400 with a 95% confidence interval. Patients were recruited as they attended the consultation where the PI and/or collaborators were present. Variables:– maternal age,– parity,– Gestational age (GA) at examination in weeks,– GA at delivery in weeks,– Interval between ultrasound and delivery,– Birth weight (BW), BW centile,– fetal gender,– onset of labor (elective cesarean section, induction of labor and spontaneous onset of labor),– mode of delivery (cesarean section for abnormal cardiotocography, failure to progress or elective, assisted delivery and spontaneous delivery),– Apgar scores at 5 minutes,– neonatal cord arterial hydrogen potential( pH)– Newborn destination: ward, neonatal, neonatal intensive care unit– Type of event triggering preterm birth:Premature rupture of membranes /Uterine dynamics + cervical modifications Statistical analysis Continuous variables were presented as mean and standard deviations (SD), median and interquartile range (IQR), while categorical variables were presented as absolute numbers and relative frequencies. Characteristics between both cohorts were compared by mean of Mann- Whitney and Fisher tests. Finally, to assess the validity of results and ensure consistency an additional multivariable analysis was performed adjusting for clinical parameters, to evaluate the odds ratio (OR) of the different determinants in the prediction of preterm birth. Finally, preterm birth incidence was calculated for specific groups selected according to the multivariable analysis result. Statistical analysis and graphs were done using Graph Pad Prism®, Mac version 9.0.1, and Stat Plus® Mac Pro version 8.0.1.s. Permissions were obtained from La Fe hospital review board and from the Valencian Autonomic Government health authorities (reference: PLUVA, date 4-2-2021). Written informed consent was retrieved to participate in the study. The authors report no conflicts of interest. Quality control: All analyses were performed on a single sample of patients who met the selection criteria and who had all the information required for the variables to be analysed. In cases where it was not possible to obtain this information, the following were excluded from the study Interventionsmode of delivery (cesarean section for abnormal cardiotocography, failure to progress or elective, assisted delivery and spontaneous delivery),